As the Fitness Editor at Stuff magazine during 2005 and 2006, Keibler wrote and modeled for her own occasional column, entitled Getting Fit with Stacy Keibler. She has appeared on the cover of that magazine twice: in June 2005 and March 2006. Maxim named Keibler #5 in its 2006 Hot 100 issue, and #70 in its 2007 Hot 100. Keibler has declined each of two invitations from Playboy to pose in the nude for its magazine. Keibler starred in a commercial for AT&T alongside Carrot Top. She also auditioned and earned a role in Big Momma's House 2, but she did not appear.

She competed in the second season of Dancing with the Stars, alongside her dance partner, Tony Dovolani. Keibler received a perfect score of 30 from the three judges for her samba dance routine in week five. This prompted the judges to nickname her a "weapon of mass seduction." Overall, Keibler and Dovolani received four perfect scores. Keibler was eliminated in the final episode, coming in third to Jerry Rice, who placed second in the final round of the competition, and Drew Lachey, the winner of the season. Two of the judges, Bruno Tonioli and Len Goodman, felt she should have at least placed second. Oddsmakers had considered her the favorite to win the competition. Keibler has appeared on MTV's Punk'd twice. In season five, Keibler took part in helping prank fellow WWE Superstar Triple H, which also included Stephanie McMahon. In season seven, however, Keibler was seen as a victim of a prank by her boyfriend, Geoff Stults.

In February 2007, Keibler began a recurring role in ABC's What About Brian. She played the role of Brian's new neighbor and love interest. This was Keibler's first major acting role, following her previous minor roles in both Bubble Boy and Pecker. Keibler guest starred on The George Lopez Show on ABC. In the fall of 2007, Keibler appeared in both The Comebacks and on ABC's drama October Road. In April 2008, she was named #64 in FHM's annual 100 Sexiest Women list. Keibler was featured in an advertisement in the 2008 SI Swimsuit issue. Keibler appeared on ABC Family's mini television series, Samurai Girl as the character Karen in September 2008. On November 23, 2008, Stacy was named the "World's Hottest Athlete" by a sixty-four contestant bracket on InGameNow. Over one-million votes were collected and Stacy defeated the Feres Twins in the finals.

• "Samurai Girl" .... Karen (6 episodes, 2008)
  - Book of the Shadow: Part 1 (2008) TV episode .... Karen
  - Book of the Shadow: Part 2 (2008) TV episode .... Karen
  - Book of the Heart: Part 1 (2008) TV episode .... Karen
  - Book of the Heart: Part 2 (2008) TV episode .... Karen
  - Book of the Sword: Part 1 (2008) TV episode .... Karen
  (1 more)
• "October Road." .... Rory Dunlop (1 episode, 2008)
  - The Fine Art of Surfacing (2008) TV episode .... Rory Dunlop
• The Comebacks (2007) .... All-American Mom
  ... aka Sports Movie (UK: DVD title)
• "What About Brian" .... Stephanie / ... (6 episodes, 2007)
  - What About Calling All Friends... (2007) TV episode .... Stephanie Conner
  - What About Secret Lovers... (2007) TV episode .... Stephanie Conner
  - What About All That Glitters... (2007) TV episode .... Stephanie Conner
  - What About Strange Bedfellows... (2007) TV episode .... Stephanie
  - What About Temptations... (2007) TV episode .... Stephanie
  (1 more)
• "George Lopez" .... Lindsay (2 episodes, 2007)
  - George Thinks Vic's Fiancée Is Lion About Being a Cheetah (2007) TV episode .... Lindsay
  - George's House Has Two Empty Wombs (2007) TV episode .... Lindsay
• Bubble Boy (2001) .... Working Girl
• "WCW Thunder" .... Ms. Hancock (2 episodes, 2000)
  - Episode dated 9 August 2000 (2000) TV episode
  - Episode dated 2 August 2000 (2000) TV episode .... Ms. Hancock
• "WCW Monday Nitro" (2 episodes, 2000)
  ... aka WCW Monday Nitro Live!
  ... aka World Championship Wrestling Monday Nitro (USA)
  - Episode #1.254 (2000) TV episode (as Ms. Hancock)
  - Episode #1.253 (2000) TV episode (as Miss Hancock)
• WCW Bash at the Beach (2000) (TV) .... Ms. Hancock
  
• "WCW Saturday Night" (1991) TV series .... Ms. Hancock (unknown episodes, 1999-2000)
  ... aka WCW Saturday Morning (USA: new title)
• Pecker (1998) (uncredited) .... Blonde on Bus