Pink took a break to write the songs for her fourth album, I'm Not Dead, which she said she titled as such because "It's about being alive and feisty and not sitting down and shutting up even though people would like you to." Pink worked with producers Max Martin, Billy Mann, Christopher Rojas, Butch Walker, Lukasz Gottwald and Josh Abraham on the album. It was released in April 2006 through LaFace Records was a substantial success throughout the world, particularly in Australia. The album reached the top ten in the U.S., the top five in the UK, number one in Germany, and sat at number one in Australia for two non-consecutive weeks, though it was Pink's lowest seller in the U.S. until the success of the single "U + Ur Hand" in early 2007. The album ranked 96th in the USA during 2007. Lead single "Stupid Girls" was Pink's biggest U.S. hit since 2002 and earned a Grammy Award nomination for Best Female Pop Vocal Performance. Its music video, in which she parodies celebrities such as Lindsay Lohan, Jessica Simpson and Paris Hilton, won the MTV Video Music Award for Best Pop Video. Subsequent singles "Who Knew" and "U + Ur Hand" were substantial hits in Australia and Europe, and they later became top ten singles in the U.S. in 2007. The non-U.S. singles were "Nobody Knows", a minor hit in the UK, Australia and Germany; "Dear Mr. President", an open letter to American President George W. Bush featuring the Indigo Girls and a top five hit in Germany, Australia and other countries; "Leave Me Alone (I'm Lonely)", a UK top forty and Australian top five entry; and "'Cuz I Can".

The album has sold over 1.1 million copies in the U.S., over 630,000 in Australia, and over 6 million worldwide. Proving very popular in Australia, with 6 top five singles, and a record breaking 62 weeks in the top 10, so far the album has gone 9 times platinum. Even as of June 2008, the I'm Not Dead album returned to the Australian Top 40 ARIA charts and remained there in November 2008 where it sits at number 15 on the chart - a total of 110 weeks in the Australian top 40 to date.

In support of the album, Pink embarked on the world I'm Not Dead Tour, for which ticket sales in Australia were particularly high—she sold approximately 307,000 tickets in Australia, giving her the record for the biggest concert attendance for an arena tour by a female artist. One of the London shows on the tour was taped and released as a DVD, Pink: Live from Wembley Arena. In 2006, Pink was chosen to sing the theme song for NBC Sunday Night Football, "Waiting All Day for Sunday Night", which is a take on "I Hate Myself for Lovin' You" by Joan Jett. She contributed a cover of Rufus's "Tell Me Something Good" to the soundtrack of the film Happy Feet, and lent her name to PlayStation to promote the PSP, a special pink edition of which was released. Pink collaborated with several other artists in 2006 and 2007, when she opened for Justin Timberlake on the American leg of his FutureSex/LoveShow Tour. She sang on the Indigo Girls album Despite Our Differences. She was featured on a remix of India.Arie's song "I Am Not My Hair" featured in the Lifetime Television film Why I Wore Lipstick to My Mastectomy. She wrote a song ("I Will") for Natalia's third album, Everything & More. "Outside of You", another song she co-wrote, was recorded by dance-pop singer Hilary Duff and released on her 2007 album Dignity. Pink recorded a song with Annie Lennox and twenty-two other female acts for Lennox's fourth solo studio album, Songs of Mass Destruction. Titled "Sing", it was written as an anthem for HIV/AIDS, according to Lennox's official site. In December 2007, a special edition Pink Box, which comprises her second to fourth albums and the DVD Live in Europe, was released in Australia and reached the top twenty on the albums chart and was credited gold (35,000+).

• Get Him to the Greek (2010) (pre-production)
  
• Catacombs (2007) (as Alecia Moore) .... Carolyn
• Charlie's Angels: Full Throttle (2003) .... Coal Bowl Starter
• Rollerball (2002) .... Rock Singer
  ... aka Rollerball (Germany)