In 2004, Kensit joined the cast of British soap opera Emmerdale, playing the character Sadie King, and also regularly featured in the third series of Channel 4's Bo Selecta and its 2005 spin-off series A Bear's Tail. Kensit's success as the soap super-bitch and in a popular comedy brought her back to the attention of the British public. In September and October 2005 she appeared as a celebrity contestant in Ant & Dec's Gameshow Marathon, progressing through to Play Your Cards Right before getting knocked out by Carol Vorderman, the eventual winner of the series. Kensit was a special guest host on The Friday Night Project on 23 June 2006 with band Placebo. She appeared as The Grand High Witch of all the World at the Children's Party at the Palace in celebration of the Queen's 80th birthday in 2006. She also became the voice of online gambling website 32red.com.

Kensit left Emmerdale in September 2006, stating that commuting to Yorkshire and the resultant time away from her sons was too stressful. As part of a dramatic week of episodes which coincided with Jeff Hordley's exit from the show. Hordley's character Cain Dingle and Sadie hatched an elaborate kidnap plan involving Tom King - they set up the transfer of £2 million from the Kings to Cain in order for Tom to be released, however Cain double crossed Sadie. Her last appearance was at an airstrip watching Cain fly away, leaving her penniless and alone. Kensit is presently a member of the Holby City cast, playing ward sister Faye Morton. She began filming in October 2006 and was on-screen from 30 January 2007. Kensit is signed to Models 1 in London.

Kensit was born in Hounslow, West London, England and attended Newland House School in Twickenham. She is the daughter of Margie, a publicist, and James Kensit nicknamed Jimmy The Dip, who was a friend of the notorious London gangsters the Kray twins. James served time in prison before Patsy was born and later went on to become an antiques dealer. Kensit was brought up as a Catholic and later attended a private Catholic school, St Catherine's in Twickenham, funded by her early professional work. Kensit's first tabloid-published relationship was with Spandau Ballet's Gary Kemp. At the time she was 15, he was 24. Kensit has been married three times, and all her husbands have been musicians. In 1988 she married Dan Donovan of band Big Audio Dynamite. In 1992 she married Jim Kerr, lead singer of Simple Minds. During her second marriage she gave birth to her first child, James. In 1997 she married Liam Gallagher from Oasis. Kensit and Gallagher had a son, Lennon, named after John Lennon. They divorced in 2000, and Kensit later claimed that she had cried every day of the marriage.

After her marriage to Gallagher ended in divorce, Kensit spoke openly about her breast augmentation, which took her bust measurement from a 32B to a 35C. She has three tattoos: on her back; above the blade of her left foot (Gaelic words); and on her ankle. She changed the tattoo of her ex-husband's name from Liam to the name of their son, Lennon. After tabloid-reported relationships with Calum Best, David Walliams, Matt Holbrook, and in 2005 with Jean-Christophe Novelli; Kensit began dating rap artist and beatboxer Killa Kela. They split up shortly after a year, Patsy claiming that she did not see a future with Killa. She soon became involved with the DJ Jeremy Healy and announced that she was marrying for a fourth time on 29 November 2007. However, on the 31 March 2008 it was reported that the pair had mutually split and called off their wedding.

• "Holby City" .... Faye Morton (63 episodes, 2007-2008)
  ... aka Holby (UK: informal short title)
       - The Weaker Sex (2008) TV episode .... Faye Morton
       - Cutting the Cord (2008) TV episode .... Faye Morton
       - We Said Some Things (2008) TV episode .... Faye Morton
       - Labour of Love (2008) TV episode .... Faye Morton
       - Or I'll Never Fall in Love (2008) TV episode .... Faye Morton
        (58 more)
• "A Bucket o' French & Saunders" .... Various Roles (2 episodes, 2007)
       - Episode #1.4 (2007) TV episode .... Various Roles
       - Episode #1.3 (2007) TV episode .... Various Roles
• The Magic Door (2007) (V) .... Rachel
• "Emmerdale Farm" .... Sadie King (61 episodes, 2004-2006)
  ... aka Emmerdale (UK: new title)
       - Episode #1.4411 (2006) TV episode .... Sadie King
       - Episode #1.4409 (2006) TV episode .... Sadie King
       - Episode #1.4315 (2006) TV episode .... Sadie King
       - Episode dated 25 December 2005 (2005) TV episode .... Sadie King
       - Episode #1.3987 (2005) TV episode .... Sadie King
        (56 more)
• The Children's Party at the Palace (2006) (TV) .... Grand High Witch
• Played (2006) .... Cindy
• "A Bear's Tail" .... Helen Hennerson (6 episodes, 2005)
       - Episode #1.6 (2005) TV episode .... Helen Hennerson
       - Episode #1.5 (2005) TV episode .... Helen Hennerson
       - Episode #1.4 (2005) TV episode .... Helen Hennerson
       - Episode #1.3 (2005) TV episode .... Helen Hennerson
       - Episode #1.2 (2005) TV episode .... Helen Hennerson
        (1 more)
• A Bear's Christmas Tail (2004) (TV) .... Helen Hennerson
• The All Star Comedy Show (2004) (TV) .... Various Roles
  ... aka Monkey Trousers (UK: new title)
• Shelter Island (2003) .... Alexandria 'Alex'
• Who's Your Daddy? (2003/I) (V) .... Heather McKay
• The One and Only (2002) .... Stella
• Bad Karma (2002) .... Maureen Hatcher/Agnes
  ... aka Hell's Gate (USA: video title)
• "Murder in Mind" .... Angela Stephenson (1 episode, 2002)
       - Flashback (2002) TV episode .... Angela Stephenson
• Darkness Falling (2002) .... Vicki
  ... aka Dark Side (USA)
  ... aka Sombres secrets (Canada: French title)
• "Casualty" .... Charlotte Leith-Jones (1 episode, 2001)
       - Happily Ever After (2001) TV episode .... Charlotte Leith-Jones
• Loves Music, Loves to Dance (2001) (TV) .... Darcy Scott
  ... aka Mary Higgins Clark's 'Loves Music, Loves to Dance' (USA: complete title)
• "Strange Frequency" (1 episode, 2001)
       - Cold Turkey (2001) TV episode
• Things Behind the Sun (2001) .... Denise
• Strange Frequency 2 (2001) (TV) .... (segment 'Cold Turkey')
• Aladdin (2000) (TV) .... Princess
• Best (2000) .... Anna