Juliette Lewis has appeared in over 40 films and made-for-TV movies. Lewis first garnered international attention and acclaim in 1991 with her turn as Danielle Bowden in Martin Scorsese's remake of Cape Fear, for which she was nominated for an Academy Award for Best Supporting Actress in 1992. Juliette was often known for her quirky behavior, and in 1996, she posed for a picture in Us Weekly which showed just a close-up of the filthy soles of her size 7 1/2 bare feet. Over the next few years, she won further critical support in Peter Medak's Romeo Is Bleeding, opposite Brad Pitt in Kalifornia, and, in perhaps her best known role as Mallory Knox opposite Woody Harrelson in Natural Born Killers. In 1995 she starred in Kathryn Bigelow's Strange Days; in the movie she sings PJ Harvey's "Hardly Wait" from the eponymous album, anticipating her later work as a singer. She received an Emmy nomination for her performance in "Hysterical Blindness" in 2003. She also appeared in the HIM music video for "Buried Alive By Love" in 2003.

Lewis has also launched a career as a solo singer and musician, leading a group called Juliette and the Licks which has released a number of recordings. She is working with rock songwriter Linda Perry, among others. Lewis has also appeared on three tracks by Electronic Music group The Prodigy's 2004 CD Always Outnumbered, Never Outgunned ("Spitfire", "Get Up Get Off", and "Hot Ride"). In 2006, Blender magazine included her in their hottest women of rock music list while saying, "[She] delivered sonically varnished melodic punk replete with purring vocals and lyrics that bash porn, pharmaceutical companies and rotten lovers (in no particular order)". Lewis appeared in Rockstar Games' Grand Theft Auto IV, providing the voice of "Juliette", the host of fictional radio station "Radio Broker". She starred in the video for the Melissa Etheridge song "Come To My Window", and has also appeared in a GAP commercial which she was dancing with Daft Punk to the tune of the song "Digital Love".

• Sympathy for Delicious (2009) (filming) (rumored)
• Whip It! (2009) (post-production) .... Dinah Might
• Metropia (2009) (post-production) (voice) .... Nina
  
• Catch and Release (2006/II) .... Maureen
• Grilled (2006) .... Suzanne
• "My Name Is Earl" .... Jesse - Bounty Hunter (1 episode, 2006)
       - The Bounty Hunter (2006) TV episode .... Jesse - Bounty Hunter
• The Darwin Awards (2006) .... Joleen
• Lightfield's Home Videos (2006)
• Daltry Calhoun (2005) .... Flora Flick
• Aurora Borealis (2005) .... Kate
• Starsky & Hutch (2004) .... Kitty
• Blueberry (2004) .... Maria Sullivan
  ... aka Blueberry: L'expérience secrète (France)
  ... aka Renegade (USA)
• Chasing Freedom (2004) (TV) .... Libby
• Cold Creek Manor (2003) .... Ruby
  ... aka Maison au fond de la baie, La (Canada: French title)
• "Free for All" (2003) TV series .... Paula (unknown episodes)
• Old School (2003) .... Heidi
• Enough (2002/I) .... Ginny
• Armitage: Dual Matrix (2002) (V) (voice: English version) .... Naomi Armitage
• Hysterical Blindness (2002) (TV) .... Beth
• "Dharma & Greg" .... September (1 episode, 2001)
       - Try to Remember This Kind of September (2001) TV episode .... September
• Picture Claire (2001) .... Claire Beaucage
• My Louisiana Sky (2001) (TV) .... Dorie Kay
• Gaudi Afternoon (2001) .... April
  ... aka Tardes de Gaudí (Spain)
• Room to Rent (2000) .... Linda