Born Diane Heidkruger in Hildesheim, Germany, Diane Kruger initially aspired to be a dancer and studied with the Royal Ballet in London. When an injury ended her hopes for a dancing career, she began modeling in Germany, where she became a finalist of the Look of the Year contest at the age of 15. She worked with renowned fashion designers Dolce & Gabbana, and her pictures graced the covers of magazines like Vogue and Elle. Moving to Paris on the advice of film director Luc Besson, Kruger decided to take up acting and enrolled in the Ecole Florent, where she became top of her class in 2002.

The same year, the actress made her big-screen debut opposite Dennis Hopper and Christopher Lambert in the indie feature The Piano Player (aka The Target), but she was not truly revealed until her role in Mon Idole, co-starring and directed by her real-life companion Guillaume Canet. After a couple more acting assignments in France, Kruger began her Hollywood career by acting alongside Josh Hartnett and Rose Byrne in Wicker Park, a remake of the 1996 French film L'Appartement. While still filming Wicker Park in 2003, she was selected among many other candidates to play the legendary beauty Helen of Troy in Wolfgang Petersen's historical epic Troy (2004). The latter film ended up being released before Wicker Park, thus becoming her high-profile introduction to the American public. She also starred opposite Nicolas Cage in Jon Turteltaub's National Treasure.

• Inglourious Basterds (2009) (filming) .... Bridget von Hammersmark
• Mr. Nobody (2009) (post-production) .... Anna
• Inhale (2009) (post-production)
  
• Pour elle (2008) .... Lisa
  ... aka Anything for Her (International: English title)
• National Treasure: Book of Secrets (2007) .... Abigail Chase
  ... aka National Treasure 2: Book of Secrets (South Africa: English title: DVD box title) (USA: DVD box title)
  ... aka National Treasure 2 (Australia)
• The Hunting Party (2007) .... Mirjana
  ... aka Lov u Bosni (Croatia)
• Âge des ténèbres, L' (2007) .... Véronica Star
  ... aka Days of Darkness (Canada: English title)
  ... aka The Age of Ignorance (International: English title)
• Goodbye Bafana (2007) .... Gloria Gregory
  ... aka Colore della liberta', Il (Italy)
  ... aka Detenuto 46664 (Italy)
  ... aka Goodbye Bafana (Germany)
  ... aka The Color of Freedom (USA: DVD title)
• Copying Beethoven (2006) .... Anna Holtz
  ... aka Klang der Stille (Germany)
• Brigades du Tigre, Les (2006) .... Constance Radetsky
  ... aka The Tiger Brigades (Australia: TV title)
• Frankie (2005) .... Frankie
• Joyeux Noël (2005) (as Diane Krüger) .... Anna Sörensen
  ... aka Merry Christmas (UK) (USA)
  ... aka Happy Christmas (International: English title)
• National Treasure (2004) .... Abigail Chase
  ... aka Sonomo (Philippines: English title: review title)